Hyperinnervation improves Xenopus laevis limb regeneration
نویسندگان
چکیده
منابع مشابه
Early limb development of Xenopus laevis.
This investigation has used histological techniques and the scanning electron microscope to establish the presence of an apical ectodermal ridge in the developing limbs of Xenopus laevis. The ridge appeared at stage 50, reached its maximal size at stage 51, and subsequently disappeared by stage 53. The course of the ridge was consistently related to a marginal sinus in the underlying mesenchyme...
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The purpose of these experiments was to compare the effects of vitamin A on developing and regenerating limbs in Xenopus laevis tadpoles. Each tadpole had one hindlimb amputated to induce regeneration while the contralateral developing limb was left intact. Tadpoles at stages 50 through 54 were treated by immersion in retinol palmitate at doses ranging from 0.3 to 75 i.u. ml-1, for periods rang...
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The heparan sulfate 6-O-endosulfatases sulf1 and sulf2 regulate multiple cellular processes and organ development. Sulfs modulate a range of heparan-sulfate-dependent extracellular pathways, including the fibroblast growth factor, bone morphogenetic protein, and wingless/wnt signaling pathways. Known patterns of sulf transcript expression together with functional experiments have implicated the...
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In certain amphibian models limb regeneration can be promoted or inhibited by the local wound bed environment. This research introduces a device that can be utilized as an experimental tool to characterize the conditions that promotes limb regeneration in the adult frog (Xenopus laevis) model. In particular, this device was designed to manipulate the local wound environment via a hydrogel inser...
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Experiments were designed to test adaptability of forelimb spike regenerates in Xenopus laevis froglets. The results show that when amputation is at the radius/ulna level, regeneration occurs in 100% of the cases and a single spike of cartilage is the result. The spike regenerates originating from radius/ulna level amputations can be used for feeding and froglet growth is only minimally comprom...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2018
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2017.10.007